One-compartment PK Model

One-compartment PK Model

One-compartment PK Model

Methods

Public methods

• PKModel$get_max_conc()

• PKModel$set_max_conc()

• PKModel$new()

• PKModel$ka_covs()

• PKModel$CL_covs()

• PKModel$V2_covs()

• PKModel$covs()

• PKModel$print()

• PKModel$simulate_ss()

• PKModel$compute_ss_auc()

• PKModel$simulate_data()

• PKModel$format_params()

• PKModel$clone()

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Method get_max_conc()

Get concentration upper bound

Usage

PKModel$get_max_conc()

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Method set_max_conc()

Set concentration upper bound

Usage

PKModel$set_max_conc(value)

Arguments

value

Upper bound for concentration, to avoid numerical issues.

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Method new()

Create model

Usage

PKModel$new(covariates)

Arguments

covariates

A list with elements ka, CL, and V2

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Method ka_covs()

Get the covariates affecting the k_a parameter.

Usage

PKModel$ka_covs()

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Method CL_covs()

Get the covariates affecting the CL parameter.

Usage

PKModel$CL_covs()

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Method V2_covs()

Get the covariates affecting the V2 parameter.

Usage

PKModel$V2_covs()

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Method covs()

Get names of all unique covariates

Usage

PKModel$covs()

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Method print()

Print the object info

Usage

PKModel$print()

Returns

nothing

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Method simulate_ss()

Simulate system in steady state

Usage

PKModel$simulate_ss(t, theta, dose, tau)

Arguments

t

output time points

theta

parameter values

dose

dose

tau

dosing interval

Returns

A vector with the same length as t, representing the concentration in the central compartment.

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Method compute_ss_auc()

Compute steady-state area under curve over one dosing interval

Usage

PKModel$compute_ss_auc(theta, dose)

Arguments

theta

parameter values

dose

dose

Returns

A numeric value

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Method simulate_data()

Simulate data with many subjects

Usage

PKModel$simulate_data(df_subjects, beta_pk = NULL, tau = 24, sigma = 0.3)

Arguments

df_subjects

Data frame with one row for each subject

beta_pk

Covariate effects

tau

Dosing interval (PK)

sigma

Noise magnitude of concentration measurements (PK)

Returns

Data frame with one row for each subject, and a DosingData object

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Method format_params()

Format list of input PK parameters to standardized format.

Usage

PKModel$format_params(beta_pk = NULL)

Arguments

beta_pk

A list of max three elements

return

A list with three elements

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Method clone()

The objects of this class are cloneable with this method.

Usage

PKModel$clone(deep = FALSE)

Arguments

deep

Whether to make a deep clone.